Endometrial cancer, the fourth most common cancer for women, occurs primarily in postmenopausal women. In 2016, approximately 60,050 women are expected to be diagnosed with cancer of the body of the uterus (endometrial cancers and uterine sarcomas), with 10,470 projected deaths.
Women may be ta higher risk of developing endometrial cancers when they have a raised level of Cadmium which is a toxic metal that mimics estrogen inside the human body. This metal may lead to an increased growth of cells inside the endometrium contributing to increased risk of endometrial cancers.
This disease mainly affects the menopausal women.
Apart from occupational exposure to cadmium. It can enter our body by these ways:
It can enter our body by food that contains cadmium metal. These foods may include crustacean shellfish such as shrimp, lobster or crab and cereals.
as absorb this metal from the soil, so heavy smokers were found to contain cadmium twice as compared to non- smokers.
Cadmium levels are related to level of smoking. Heavy smokers may have twice as much cadmium, and moderate smokers’ cadmium burden may increase by approximately sixty percent compared to non-smokers.
Because the estimated biological half-life of cadmium is from 10 to 30 years, only a small fraction of inhaled or ingested cadmium is excreted, and the body burden increases over time. Women generally have higher cadmium levels than men.
Endometrial cancers have been associated with estrogen exposure. As cadmium mimics estrogen, it can also lead to an increased risk of endometrial cancers.
It was suggested that even low levels of cadmium may significantly shortens the protective caps of DNA on chromosomes’ ends termed telomeres. Telomeres are associated with aging and shortened telomeres may increases the risks of cardiovascular diseases, cancers, diabetes and other age-related conditions.
1- Friberg L, Elinder CG, Kjellstrom T, Nordberg GF. Cadmium and health: a toxicological and epidemiological appraisal, volume II, effects and response. Boca Raton, FL: CRC Press. 1985.
3- McElroy JA, Shafer MM, Trentham-Dietz A, Hampton JM, Newcomb PA. Cadmium exposure and breast cancer risk. J Natl Cancer Inst. 2006;98: 869–873. pmid:16788160